Wikimore

Setastine
Identifiers
	IUPAC name 1-[2-[1-(4-chlorophenyl)-1-phenyl-ethoxy]ethyl]azepane;
CAS Number	64294-95-7; HCl: 59767-13-4 ;
PubChem CID	43082;
ChemSpider	39258;
UNII	6G3OCF528J; HCl: T2MB6P84ON ;
CompTox Dashboard (EPA)	DTXSID30867067 ;
Chemical and physical data
Formula	C22H28ClNO
Molar mass	357.92 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC(C1=CC=CC=C1)(C2=CC=C(C=C2)Cl)OCCN3CCCCCC3;

Setastine (Loderix) is an antihistamine used to treat allergies and rhinitis.^[1]^[2]

Pharmacology

Setastine penetrates the blood-brain-barrier poorly so it is only mildly sedating compared to related molecules like diphenhydramine.^[3]

↑ Lantos A, Tóth A, Zsiray M (1991). "Loderix (setastine) tablets in the treatment of allergic rhinoconjunctivitis". Therapia Hungarica. 39 (1): 22–24. PMID 1677500.
↑ Hirschberg A, Ribári O, Krasznai M (1989). "Results obtained with Loderix tablet in chronic rhinitis patients". Therapia Hungarica. 37 (4): 202–204. PMID 2576575.
1 2 Porszász J, Varga F, Porszász KG, Szolscányi J, Barthó L, Petöcz L, Kápolnai L (December 1990). "Pharmacology of the new H1-receptor antagonist setastine hydrochloride". Arzneimittel-Forschung. 40 (12): 1340–1345. PMID 1982751.

Identifiers


IUPAC name 1-[2-[1-(4-chlorophenyl)-1-phenyl-ethoxy]ethyl]azepane
CAS Number	64294-95-7 HCl: 59767-13-4^Y
PubChem CID	43082
ChemSpider	39258
UNII	6G3OCF528J HCl: T2MB6P84ON^Y
CompTox Dashboard (EPA)	DTXSID30867067
Chemical and physical data
Formula	C₂₂H₂₈ClNO
Molar mass	357.92 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CC(C1=CC=CC=C1)(C2=CC=C(C=C2)Cl)OCCN3CCCCCC3