\documentclass[12pt,border=-3pt,tikz,class=scrartcl]{standalone}
\usepackage[T1]{fontenc}
\usepackage[latin1]{inputenc}
\usepackage{times}
\usepackage{mathtools,amssymb}
\usepackage{pgfplots}
\pgfplotsset{compat=1.12}
\usetikzlibrary{positioning,calc,arrows,fit,backgrounds,decorations.text,shapes}
 
\usepackage{chemfig,chemmacros}
\renewcommand*{\familydefault}{\sfdefault}
\renewcommand*\printatom[1]{\ensuremath{\mathsf{#1} } }
\setatomsep{1.5em}
\setdoublesep{.6ex}
\setarrowdefault{,1,ultra thick}
\setbondstyle{thick,cap=round}
 
\pagestyle{empty}
\thispagestyle{empty}
\begin{document}
\begin{tikzpicture}[>=stealth']
	\draw 
		node at (-2,2) (a) {\Large A}	node at (2,2) (g) {\Large G}
		node at (-2,-2) (c) {\Large C}	node at (2,-2) (t) {\Large T}
	;
	\draw [<->,fill=blue,draw=blue,ultra thick] (a) -- (g) node [pos=.5,blue,above] (t1) {\small Transitions};
	\node [above=of t1] {\small purines};
	\draw [<->,draw=blue,fill=blue,ultra thick] (c) -- (t) node [pos=.5,blue,below] (t2) {\small Transitions};
	\node [below=of t2] {\small pyrimidines};
	\draw [<->,fill=red,draw=red,ultra thick] (c) -- (g);
	\draw [<->,fill=red,draw=red,ultra thick] (a) -- (t);
	\draw [<->,fill=red,draw=red,ultra thick] (a) -- (c) node [pos=.5,red,left] {\small Transversions};
	\draw [<->,fill=red,draw=red,ultra thick] (g) -- (t) node [pos=.5,red,right] {\small Transversions};
	\node [above left=-10pt of a] {\chemname{
		\chemfig{*6(=N-*5(-N(-[6,.6,,,draw=none]H)-=N-)=-(-NH_2)=N-)}
		}{adenine}
	};
	\node [above right=-10pt of g] {\chemname{
		\chemfig{*6((-H_2N)=N-*5(-N(-[6,.6,,,draw=none]H)-=N-)=-(=O)=HN-[,,2])}
		}{guanine}
	};
	\node [below right=-10pt of t] {\chemname{
		\chemfig{*6(-N(-[6,.6,,,draw=none]H)-(=O)-NH-(=O)-(-)=)}
		}{thymine}
	};
	\node [below left=-10pt of c] {\chemname{
		\chemfig{*6(-N(-[6,.6,,,draw=none]H)-(=O)-N=(-NH_2)-=)}
		}{cytocine}
	};
\end{tikzpicture}
\end{document}