English: Degradation series contrasting strained and unstrained ROIs. Top Left) Entire field of view showing a collagen network, reconstituted around functionalized micropipettes, degrading in the presence of MMP-8. Bar  = 10 µm. Top Right) ROI #4 - unstrained fibrils, including two perpendicular fibrils. Bar  = 1 µm. Bottom Left) ROI #8 - strained fibrils. Note some fibrils within the strained ROI are perpendicular to the strain direction (Black Arrow), and these fibrils disappear before the strained fibrils. Bar  = 1 µm. Bottom Right) Normalized, integrated edge intensity from ROI #4 (unstrained) and ROI#8 (strained) versus time.