English: Hyperactivity in PatDp(dist2). Video of a 6 day old PatDp(dist2) and wild-type littermate showing almost continual activity and rapid movement with paddling of the front feet in the PatDp(dist2) but very little movement in the wild-type. The PatDp(dist2) has the characteristic tail kink or bend, and by 6 days is clearly smaller than the wild-type but oedema and a chunky appearance are no longer evident. The mice have a genetic background that is 50% Mus musculus castaneus and 50% laboratory mouse. On this background there was slightly better survival of PatDp(dist2) to 7 days (10/23) compared with 3/28 on an entirely laboratory mouse background (P = 0.0106 (Fisher’s exact test, 2-tailed) but no difference in survival to weaning.