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Summary

Description

English: Animation showing the hypothesized conformational changes of the G protein throughout the G protein cycle. The GDP-bound heterotrimer (gray) binds to activated receptor (blue), and the nucleotide-binding pocket region consisting of β6-α5, the P-loop and switch 2 are perturbation, resulting in GDP (purple) release. Subsequently, the helical domain of Gα(GDP) opens away from the receptor-anchored Ras domain, which allows GDP release and GTP (orange) to enter. Reorientation of Gα caused by GTP binding leads to dissociation of the receptor and Gβγ (Gβ; green and Gγ; cyan). GTP hydrolysis leads to rebinding of Gβγ to Gα in order to restart the G protein signaling cycle.

Date

2 August 2016

Source

S1 Video from Kim M, Kim Y, Kim H, Jeon T, Choi J, Chung K, Kim M (2016). "Computational Simulation of the Activation Cycle of Gα Subunit in the G Protein Cycle Using an Elastic Network Model". PLOS ONE. DOI:10.1371/journal.pone.0159528. PMID 27483005. PMC: 4970668.

Author

Kim M, Kim Y, Kim H, Jeon T, Choi J, Chung K, Kim M

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Summary