During disaster response, key resources are supplied from a variety of channels including: government agencies, volunteer organizations, commercial businesses, educational institutions and others. While many of the entities have efficient internal methods of communication and coordination, global collaboration has historically been hindered by political, social, and technological challenges. Following Hurricane Katrina this resulted in over resourcing of some in need areas with little or no resources reaching others. While there is little argument that a global approach to disaster response should be adopted, political and technical challenges surrounding the integration and ownership of such a system have prevented its emergence. This thesis examines the current challenges to collaboration between responding entities and proposes self-synchronization using a distributed, highly scalable, Web application based on cloud computing technologies to facilitate communication between a broad range of public and private entities without requiring them to compromise security or competitive advantage. The proposed design applies the unique benefits of cloud computing architectures such as automatic scaling, geographic distribution, and query performance to the disaster response domain.