File:12943 2021 1311 Fig1 HTML.webp
Summary
| Description |
English: Antigen-encoding mRNA expression by alphaviral replicon RNA. a DNA plasmid–based saRNA uses plasmid DNA as a carrier to transfer replicase genes and the transgene into the nucleus where the mRNA is translated. b the virus-like particle packages saRNA and delivers replicon RNA to the cytosol by the receptor-mediated endocytosis, forming an endosome. c in vitro transcribed saRNAs are delivered in saline or synthetic formulations. |
| Date | |
| Source | Wang, Y., Zhang, Z., Luo, J. et al. mRNA vaccine: a potential therapeutic strategy. Mol Cancer 20, 33 (2021). https://doi.org/10.1186/s12943-021-01311-z |
| Author | Yang Wang, Ziqi Zhang, Jingwen Luo, Xuejiao Han, Yuquan Wei, and Xiawei Wei |
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