File:Increased-Vulnerability-of-Human-Ventricle-to-Re-entrant-Excitation-in-hERG-linked-Variant-1-Short-pcbi.1002313.s004.ogv

Summary

Description
English: N588K reentry in realistic 2D geometry. Re-entrant spiral waves generated by the application of a premature S2 stimulus into the refractory and partially recovered region of an excitation wave after a delay of 241 ms rom the initial wave stimulus under the N588K (SQT1 mutant) condition. The induced spiral waves transition from transmural re-entry with tip rotating within the ventricle wall to anatomical re-entry with tip rotating around the ventricle boundary. The spiral waves persist under the SQT1 condition and break up forming regenerative multiple re-entrant wavelets.
Date
Source Video S4 from Adeniran I, McPate M, Witchel H, Hancox J, Zhang H (2011). "Increased Vulnerability of Human Ventricle to Re-entrant Excitation in hERG-linked Variant 1 Short QT Syndrome". PLOS Computational Biology. DOI:10.1371/journal.pcbi.1002313. PMID 22194679. PMC: 3240585.
Author Adeniran I, McPate M, Witchel H, Hancox J, Zhang H
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Category:Action potentials Category:Ether-a-go-go potassium channels Category:Heart ventricles Category:Cardiovascular models Category:Ventricular function Category:Media from PLOS Computational Biology Category:Uploaded with Open Access Media Importer Category:Videos from open-access scholarly articles Category:Uploaded with Open Access Media Importer and needing category review Category:Ogv videos Category:Video display resolution 529 x 333
Category:Action potentials Category:CC-BY-2.5 Category:Cardiovascular models Category:Ether-a-go-go potassium channels Category:Heart ventricles Category:Media from PLOS Computational Biology Category:Ogv videos Category:Uploaded with Open Access Media Importer Category:Uploaded with Open Access Media Importer and needing category review Category:Ventricular function Category:Video display resolution 529 x 333 Category:Videos from open-access scholarly articles