File:Hepatitis B virus v2 (3).svg

Summary

Description
English: Simplified drawing of the Hepatitis B virus particle and surface (surplus) antigen. Created by en:User:GrahamColm
Date 14 November 2007 (original upload date)
Source Transferred from en.wikipedia
Author Original uploader was TimVickers at en.wikipedia
Permission
(Reusing this file)		 Released into the public domain (by the author).
Other versions

[edit]
SVG development
InfoField

Extended description

The structure of the Hepatitis B virus as first described by Dane & al.[1] and Jokelainen, Krohn & al.[2] in 1970:

Virion

The hepatitis B virion, is a complex, spherical, double shelled particle with a diameter of 42 nm.[1][2][3]

  • Within the membrane sphere is a 2 nm thick icosahedral nucleocapsid inner core composed of protein (HBcAg) with a diameter of 27 nm.[2] When viewed through an electron microscope the inner core may appear pentagonal or hexagonal,[2] depending on the relative position of the sample.

The virion was initially referred to as the Dane particle.[4] Only after Baruch Blumberg received the Nobel Prize in Medicine in 1976 was it universally accepted that the particle is a virus and the infectious agent of Hepatitis B.

Australia antigen (HBsAg)

The serum of infected patients also contain small spherical and rod-shaped particles with a diameter of ca. 20 nm,[5] consisting of surplus virus-coat material containing the HBsAg antigen.[1][2] This antigen was first discovered by Baruch Blumberg in 1965 in the blood of Australian aboriginal people and initially known as "Australia antigen".[6] It was shown to be associated with "serum hepatitis" by A. M. Prince in 1968.[7]

The outer membrane of the virion is sometimes extended as a tubular tail on one side of the virus particle (not shown);[2][3] these virion "tails" are identical to the small particles.[2][3]

The hepatitis B e antigens (shown) are considered not part not part of the viral particle.

References

  1. 1 2 3 D.S. Dane , C.H. Cameron , Moya Briggs (1970). "Virus-Like Particles in Serum of Patients with Australia-Antigen-Associated Hepatitis". The Lancet 295: 695–698. DOI:10.1016/S0140-6736(70)90926-8.
  2. 1 2 3 4 5 6 7 8 9 10 11 12 P. T. Jokelainen, Kai Krohn, A. M. Prince and N. D. C. Finlayson (1970). "Electron Microscopic Observations on Virus-Like Particles Associated with SH Antigen". J Virol. 6 (5): 685-689. ISSN 1098-5514.
  3. 1 2 3 4 5 6 The hepatitis B virus. WHO.
  4. 1 2 Almeida J D, Rubenstein D & Scott E J. (1971). "New antigen-antibody system in Australia-antigen-positive hepatitis". The Lancet 298 (7736): 1225–7. DOI:10.1016/S0140-6736(71)90543-5.
  5. ↑ Bayer, M. E., B. S. Blumberg, and B. Werner (1968). "Particles associated with Australia antigen in the sera of patients with leukemia, Down's syndrome and hepatitis.". Nature (London) 218: 1057-1059.
  6. ↑ Baruch S. Blumberg, Harvey J. Alter, and Sam Visnich (Jul 1984). "Landmark article Feb 15, 1965: A 'new' antigen in leukemia sera. By Baruch S. Blumberg, Harvey J. Alter, and Sam Visnich". JAMA 252 (2): 252–7. DOI:10.1001/jama.252.2.252. PMID 6374187. ISSN 0098-7484.
  7. ↑ Prince, A. M. (1968). "An antigen detected in the blood during the incubation period of serum hepatitis". Proc. Nat. Acad. Sci. U.S.A. 60: 814-821.

Licensing

This work has been released into the public domain by its author, TimVickers, at the English Wikipedia project. This applies worldwide.

In case this is not legally possible:
TimVickers grants anyone the right to use this work for any purpose, without any conditions, unless such conditions are required by law.

Category:PD-user#Hepatitis%20B%20virus%20v2%20(3).svg

Original upload log

The original description page was here. All following user names refer to en.wikipedia.
  • 2007-11-14 18:14 TimVickers 843×577× (81917 bytes) Simplified drawing of the Hepatitis B virus particle and surface (surplus) antigen


Category:Hepatitis B virus Category:SVG viruses
Category:Hepatitis B virus Category:PD-user Category:SVG viruses Category:Valid SVG created with Inkscape-hand Category:Valid SVG created with Text Editor